US Injectable Compounding Pharmacy Market To Witness Significant Growth Due To R&D in Injectable Drugs

 

Compounding pharmacy involves combining or mixes of APIs to develop a customized drug for various diseases. An injectable compounded medication is a sterile drug to be administered into the body using a needle and syringe or an I.V. administration set and needle device. The U.S. injectable compounding pharmacy market is driven by R&D in injectable drugs. For instance, November 2020, Paradigm Biopharmaceuticals Ltd. initiated a Phase II clinical trial of subcutaneous injectable Pentosan Polysulphate Sodium (iPPS), in patients with the ultra-rare orphan disease Mucopolysaccharidosis Type 1 (MPS-1).

One of the most common compounded injectable medications used in the U.S. injectable compounding pharmacy market include, Acetylcysteine 100 mg/mL, Acetyl-L-Carnitine 200 mg/mL, Amino Acid, Arginine HCL, Arginine HCL, Biotin, Carnitine, and Chromium. Acetyl-L-carnitineis an acetylated form of L-carnitine. It is naturally produced by the human body, and it is available as a dietary supplement.

One of the most important issues involved with products in the U.S. injectable compounding pharmacy market is sterility. All injectables must be sterile before they are administered, and most compounding pharmacies are reputable enough to follow this requirement. Sterile compounds are usually combined with plastic microparticles that are coated on both sides with a sterile material to increase their effectiveness. These microparticles should not be injected under any circumstances, as even tiny amounts of bacteria or other contaminants may cause adverse reactions. If a compound requires mixing, it is always best to thoroughly mix all components first by running the mixture through a sieve.

A major problem involved with medications in U.S. injectable compounding pharmacy market is contamination. Any drug can be tainted by a wide range of contaminants, from biological matter such as human or animal tissues and cells, to chemicals and additives. To improve the sterility of compounded injectable medications, many pharmacies process them through steam distillation. Although this process does remove the majority of contaminants, it also removes the phthalate ester, which is common contaminants found in most medicated products. Because of this, it is difficult to find any compound that has been specifically tested for phthalate levels.

The other issue with medications in the U.S. injectable compounding pharmacy market is contamination of the actual medication itself. Many medications are manufactured by combining different chemical compounds, creating multiple inactive ingredients. In these cases, a reputable compounding pharmacy will make sure the correct amount of each ingredient is included, thereby preventing contamination. In instances where ingredients have been mixed and the potency of each is unknown, it may be necessary to request that the medication be directly compounded by a trained staff member.

Although medications in the U.S. injectable compounding pharmacy market are generally very stable, they will not maintain their effectiveness over time the way that pure drugs do. Compound ingredients will generally retain their stability if they are stored in an air-tight container, such as a glass ampoule. Additionally, it is important to keep a close eye on the shelf life of all medications, especially those for serious conditions, as there can be a small change to their stability with each use. It is impossible to predict how long a medication will retain its stability, but it can be safe to plan to use a compounded injectable only after receiving a physician's explicit approval.