Antisense Oligonucleotides Market To Grow Due To High Prevalence Of Genetic Disorders And Cancer

 

Antisense Oligonucleotides Market

Antisense oligonucleotides (ASOs) are single-stranded DNA molecules that are changed to restrict the expression of their mRNA targets in order to regulate inappropriate gene expression in pathological circumstances. Spinal muscular atrophy, Duchenne muscular dystrophy, and other hereditary illnesses are treated with ASOs.

Market Dynamics

The market for antisense oligonucleotides is predicted to rise due to the high prevalence of cancer. According to the American Cancer Society, there will be 1,762,450 new cancer cases diagnosed and 606,880 cancer deaths in the United States year 2019.

Expanding interest in R&D of cancer is relied upon to offer worthwhile development openings for major parts in antisense oligonucleotides market. For example, as indicated by the National Cancer Research Institute (NCRI), cancer research financing by NCRI accomplices stretched around US$ 750 million out of 2018/19. In addition, high pervasiveness of genetic disorders is likewise expected to help in development of the market. For example, as indicated by the investigation, 'Transporter recurrence of SMN1-related spinal solid decay in north Indian populace: The requirement for populace based screening program' distributed in American Journal of Medical Genetics in October 2020, the transporter recurrence of Spinal Muscular Atrophy (SMN)1 cancellation was 1 of every 38 (16 out of 606).

The antisense oligonucleotides industry is projected to be hampered by the lack of major clinical trials verifying the encouraging outcomes reported with antisense oligonucleotides in preclinical models.

Competitive Analysis

Major players in operating in the antisense oligonucleotides market include, Ionis Pharmaceuticals Inc., Aligos Therapeutics, Inc., Sarepta Therapeutics Inc., Biogen Inc., Alnylam Pharmaceuticals Inc., Antisense Therapeutics Ltd., Isarna Therapeutics GmbH, Arrowhead Pharmaceuticals Inc., Atlantic pharmaceuticals Inc., Enzon Pharmaceuticals Inc., Bio-Path Holdings Inc., Glaxo smith Kline Plc., Gene Signal International SA., Geron Corporation, Gradlis Inc., ICO Therapeutics Inc., Aptose Biosciences Inc., Marina Biotech Inc., miRagen Therapeutics Inc., Synlogic Inc., OncoGenex Pharmaceuticals Inc., Pharmaxis Ltd., Rexahn Pharmaceuticals Inc., Regulus Therapeutics Inc., and Rxi Pharmaceuticals Inc.

Major players in operating in the antisense oligonucleotides market are focused on adopting partnership strategies to enhance their market share. For instance, in December 2020, Aligos Therapeutics, Inc. entered into an Exclusive License and Research Collaboration Agreement with Merck, under which Merck and Aligos will apply Aligos’ oligonucleotide platform technology to discover, research, optimize and develop oligonucleotides directed against a non-alcoholic steatohepatitis (NASH) target and up to one additional target of interest in the cardiometabolic/fibrosis space.


Location: India

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